Mariella G. Filbin

This study shows that targeting SAGA/ATAC complexes disrupts chromatin regulation and cholesterol metabolism in diffuse midline glioma, leading to reduced tumor growth.

The paper uses single-cell and spatial multi-omic analyses to characterize cellular diversity in RTK-fused gliomas across pediatric age groups, identifying distinct cancer cell states and myeloid subgroups.

This study identifies elongin B as a key regulator of Pol2 elongation in H3K27M-mutant diffuse midline glioma, showing its role in maintaining chromatin and transcriptional dysregulation.

This study integrates single-cell and spatial transcriptomics with live-cell imaging to characterize tumor heterogeneity in supratentorial ependymomas, revealing distinct progenitor-like states and spatial organization patterns.

This study shows serotonergic neurons promote high-grade glioma growth via 5HT2A receptor activation, with psychedelic drugs enhancing this effect.

This study identifies CD155 as a key regulator of tumor growth and immune evasion in diffuse midline glioma, showing that targeting CD155 or its downstream target FOXM1 can inhibit tumor progression.

This paper introduces RECODR, a computational pipeline that tracks transcriptome changes in cancer development and treatment to predict resistance mechanisms and design effective therapies.