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Activity-gated exocytosis drives myelin remodeling required for adult learning

This study identifies activity-dependent exocytosis in mature oligodendrocytes as a mechanism driving myelin remodeling necessary for adult learning.

Gliomas phenocopy an inborn error of metabolism to drive neuronal activity and tumor growth

This study identifies GAA accumulation in gliomas as a driver of neuronal activity and tumor growth, linking cancer metabolism to neuroscience through GABAA receptor activation.

Juvenile influenza can impair myelin development and adult behavior through chemokine signaling in mice

This study shows that juvenile influenza infection in mice impairs myelin development and leads to lasting cognitive and behavioral issues, which can be mitigated by inhibiting the chemokine receptor CCR3.

Serotonergic neuron-glioma interactions drive high-grade glioma pathophysiology

This study shows serotonergic neurons promote high-grade glioma growth via 5HT2A receptor activation, with psychedelic drugs enhancing this effect.

Neuroligin-3 interaction with CSPG4 regulates normal and malignant glial precursors through PIEZO1

This study identifies the NLGN3-CSPG4-PIEZO1 axis as a regulator of glial precursor cell state and glioma proliferation through mechanosensitive signaling.

Cholinergic Neuronal Activity Promotes Diffuse Midline Glioma Growth through Muscarinic Signaling

This study shows that cholinergic neuron activity promotes both healthy OPC and DMG proliferation through muscarinic receptors, with specific nuclei driving growth in different brain regions.

GABAergic neuron-to-glioma synapses in diffuse midline gliomas

This study identifies functional GABAergic neuron-to-glioma synapses in diffuse midline gliomas that promote tumor proliferation and shows that drugs modulating GABAergic signaling affect glioma growth.

Myelin plasticity in ventral tegmental area is required for opioid reward

The paper shows that myelin plasticity in the ventral tegmental area, regulated by dopaminergic activity, is essential for opioid reward and dopamine release dynamics.

Glioma synapses recruit mechanisms of adaptive plasticity

This study shows that BDNF-TrkB signaling promotes malignant synaptic plasticity in gliomas, enhancing tumor progression through mechanisms similar to long-term potentiation in the healthy brain.

BMAL1 loss in oligodendroglial lineage cells dysregulates myelination and sleep

The paper shows BMAL1 regulates oligodendroglial maintenance and myelination, which affects sleep, and links this to MS pathology.

Mild respiratory SARS-CoV-2 infection can cause multi-lineage cellular dysregulation and myelin loss in the brain

Respiratory-restricted SARS-CoV-2 infection in mice, without brain virus, drives white matter microglial reactivity, impaired neurogenesis, oligodendrocyte depletion and myelin loss lasting at least 7 weeks.

Monosynaptic tracing maps brain-wide afferent oligodendrocyte precursor cell connectivity

The paper maps brain-wide afferent connectivity to oligodendrocyte precursor cells using monosynaptic tracing in adult mice, revealing extensive inputs from functionally interconnected cortical and thalamic regions.