Xinyuan Li

This study identifies biallelic LRRK2 loss-of-function variants as a cause of interstitial lung disease, showing reduced LRRK2 protein and impaired lung function in affected individuals.

This study confirms the role of Notch signaling in dysplastic lung repair using genetic inhibition in mice, showing its impact on cell expansion but not differentiation.

The paper identifies an injury-induced tissue niche (iTCH) in the lung that coordinates regenerative and disease responses through mesenchymal plasticity and signaling pathways.