Andrew E. Vaughan

A Bioactive Phospholipid Promotes Rapid Progenitor Lung Progenitor Activation via AP-1

This study identifies lysophosphatidic acid (LPA) as a key bioactive lipid that promotes alveolar type 2 cell progenitor activation via AP-1 transcription factors during lung regeneration.

Influenza-induced tuft cell expansion alters ILC-mediated inflammation

This study shows that influenza-induced tuft cell expansion interacts with ILC2s to regulate inflammation, with tuft cell deficiency altering ILC subsets and inflammatory responses.

Dysplastic Epithelial Repair Propagates Chronic Pathology Through the Paracrine Transformation of Pulmonary Fibroblasts

The paper shows dysplastic basal cells induce an inflammatory fibroblast phenotype through IL-1 secretion, promoting chronic inflammation and fibrosis.

Examining the Role of Notch Signaling in Dysplastic Lung Repair

This study confirms the role of Notch signaling in dysplastic lung repair using genetic inhibition in mice, showing its impact on cell expansion but not differentiation.

Impaired AMPK Control of Alveolar Epithelial Cell Metabolism Promotes Pulmonary Fibrosis

The paper identifies impaired AMPK signaling in AT2 cells as a driver of pulmonary fibrosis and shows restoring AMPK alleviates fibrosis in vivo.

A longitudinal atlas of post-viral lung regeneration reveals persistent injury-associated cell states

This study maps the temporal sequence of mouse lung regeneration after viral injury, identifying persistent injury-associated cell states and their role in alveolar niche repair.

Disruption of Immune Responses By Type I Diabetes Exacerbates SARS-CoV-2 Mediated Lung Injury

This study shows that Type I Diabetes Mellitus worsens SARS-CoV-2-induced lung injury in mice by impairing immune responses and increasing inflammation.

ΔNp63 drives dysplastic alveolar remodeling and restricts epithelial plasticity upon severe lung injury

This study identifies ΔNp63 as a driver of dysplastic alveolar remodeling by restricting fate plasticity of p63+ progenitors in severe lung injury.

Orthotopic Transplantation and Engraftment of Human Induced Pluripotent Stem Cell-Derived Alveolar Progenitor Cells into Murine Lungs

This paper demonstrates the orthotopic transplantation of human induced pluripotent stem cell-derived alveolar progenitor cells into murine lungs to create a humanized lung model.