Cancer BiologyCell Death and DiseasePeer-reviewed
Mitochondrial Integrated Stress Response Activation Creates a Therapeutic Vulnerability to MCL-1 Inhibition in Acute Myeloid Leukemia
Lauren Brakefield, Amit Budhraja, Peter A. Hall…·Joseph T. Opferman
This study identifies co-targeting of MCL-1 and ETC complex I as a synergistic therapy for high-risk AML, showing improved viability reduction and survival in preclinical models.
DOI 10.1038/s41419-026-09037-w