GeneticsbioRxivPreprint
Synthetic analogue of adrenocorticotropic hormone, ACTH(4-7)PGP delays neurological manifestations in diseases of mucopolysaccharidosis III spectrum by reducing neuroinflammation and rescuing neurotransmission, synaptogenesis, and axonal demyelination
Travis Mooree, Patricia Dubot, Gustavo Monteiro Viana…·Alexey V. Pshezhetsky
The paper tests a synthetic peptide ACTH(4-7)PGP in MPS III mouse models, showing it improves synaptic function, reduces neuroinflammation, and extends lifespan.
DOI 10.64898/2026.02.20.707013