Synthetic analogue of adrenocorticotropic hormone, ACTH(4-7)PGP delays neurological manifestations in diseases of mucopolysaccharidosis III spectrum by reducing neuroinflammation and rescuing neurotransmission, synaptogenesis, and axonal demyelination
Travis Mooree, Patricia Dubot, Gustavo Monteiro Viana, Poulomee Bose, Erjun Zhang, Behzad Nasseri, Xuefang Pan, Derek N. Robertson, Lara Feulner, Mahsa Taherzadeh, Patrick Piet Van Vliet, Éric Bonneil, Shaukat Khan, Longguo Zhang, Francesco Attanasio, , Alexey V. Pshezhetsky
The paper tests a synthetic peptide ACTH(4-7)PGP in MPS III mouse models, showing it improves synaptic function, reduces neuroinflammation, and extends lifespan.
bioRxiv · Feb 24, 2026 · PreprintGenetics