Author

Tae–Hoon Shin

National Institutes of HealthORCID 0000-0002-9619-8554Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:rat· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Byung‐Chul LeeiD· 2 shared Cynthia E. DunbariD· 2 shared So Gun HongiD· 2 shared Yifan ZhouiD· 2 shared Aisha A. AljanahiiD· 1 shared Anthony CookiD· 1 shared Barbara J. FlynniD· 1 shared Bradley S. Toms· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersGenetics

Byung‐Chul LeeORCID

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2 papers

Recent·Most cited

Investigation of the Impact of Clonal Hematopoiesis on Severity and Pathophysiology of COVID-19 in Rhesus Macaques

Tae–Hoon Shin, Yifan Zhou, Byung‐Chul Lee, So Gun Hong, Shayne F. Andrew, Barbara J. Flynn, Matthew Gagné, John-Paul M. Todd, Ian N. Moore, Anthony Cook, Mark G. Lewis, Kathryn E. Foulds, Robert A. Seder, Daniel C. Douek, Mario Roederer, Cynthia E. Dunbar

This study investigates how clonal hematopoiesis affects COVID-19 severity and pathophysiology in rhesus macaques, finding prolonged inflammation and higher viral persistence in CH animals.

Frontiers in Veterinary Science · Jul 6, 2023Peer-reviewedGenetics

Validation and Long-Term Follow Up of CD33 Off-Targets Predicted In Vitro and In Silico Using Error-Corrected Sequencing in Rhesus Macaques

Aisha A. Aljanahi, Cícera Regina Lazzarotto, Shirley Chen, Tae–Hoon Shin, Stefan Cordes, Isabel Jabara, Yifan Zhou, David J. Young, Byung‐Chul Lee, Kyung–Rok Yu, Yuesheng Li, Bradley S. Toms, Ilker Tunc, So Gun Hong, Lauren L. Truitt, , Cynthia E. Dunbar

The paper validates off-target effects of CRISPR/Cas9 in rhesus macaques using error-corrected sequencing, showing that in vitro and in silico methods have limited predictive accuracy.

bioRxiv · Jul 5, 2020 · PreprintMolecular Biology