Author

Lucas Le

University of California, IrvineORCID 0009-0005-7794-5736Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Dominic I. JavonilloiD· 2 shared Kate Inman TsourmasiD· 2 shared Kellie Fernandez· 2 shared Kim N. GreeniD· 2 shared Susana FurmaniD· 2 shared Thomas E. LaneiD· 2 shared Collin PachowiD· 1 shared Dequina NicholasiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Dominic I. JavonilloORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintFeb 25, 2026

Characterization of effects of a neurotropic murine coronavirus infection on Alzheimer's disease neuropathology of 5xFAD mice

Dominic I. Javonillo, Susana Furman, Lucas Le…·Thomas E. Lane

This study investigates how JHMV-induced encephalitis affects Aβ plaque pathology in 5xFAD mice, finding increased T cell infiltration and altered myeloid cell responses.

DOI 10.64898/2026.02.23.707587

mousespatial transcriptomics

𝕏 PostBluesky

PathologybioRxivPreprintDec 22, 2025

Infection of 5xFAD mice with a mouse-adapted SARS-CoV-2 does not alter Alzheimer's disease neuropathology yet induces wide-spread changes in gene expression across diverse cell types

Susana Furman, Latifa Zayou, Kate Inman Tsourmas…·Thomas E. Lane

This study infects 5xFAD mice with SARS-CoV-2 and finds no change in Alzheimer's pathology but widespread gene expression changes in multiple cell types.

DOI 10.64898/2025.12.19.695600

mousebulk RNA-seq

𝕏 PostBluesky