Kim N. Green

Characterization of effects of a neurotropic murine coronavirus infection on Alzheimer's disease neuropathology of 5xFAD mice

This study investigates how JHMV-induced encephalitis affects Aβ plaque pathology in 5xFAD mice, finding increased T cell infiltration and altered myeloid cell responses.

Infection of 5xFAD mice with a mouse-adapted SARS-CoV-2 does not alter Alzheimer's disease neuropathology yet induces wide-spread changes in gene expression across diverse cell types

This study infects 5xFAD mice with SARS-CoV-2 and finds no change in Alzheimer's pathology but widespread gene expression changes in multiple cell types.

Generation of an inducible destabilized-domain Cre mouse line to target disease associated microglia

The paper develops a mouse model to specifically target disease-associated microglia (DAMs) using an inducible Cre system and validates its specificity through spatial transcriptomic analysis.

APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology

The paper investigates how the APOE Christchurch variant affects microglial responses to amyloid and tau pathology in mouse models, finding it enhances plaque-related responses but suppresses tau-related inflammation.

Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer's Disease

This study uses spatial transcriptomics and single-nucleus RNA-seq to compare genetic and sporadic Alzheimer's Disease, finding similar spatial and cell-type specific changes between sporadic AD and AD in Down Syndrome.

Myeloid-derived β-hexosaminidase is essential for neuronal health and lysosome function: implications for Sandhoff disease

This study shows that myeloid-derived β-hexosaminidase supports neuronal lysosomal function and that microglial replacement can reverse Sandhoff disease symptoms.

A Trem2*R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques

Systematic phenotyping and characterization of the 3xTg-AD mouse model of Alzheimer's Disease

This paper characterizes the 3xTg-AD mouse model of Alzheimer's Disease across its lifespan and compares it with the 5xFAD model to assess pathology and model drift.

Systematic Phenotyping and Characterization of the 5xFAD mouse model of Alzheimer's Disease

The paper performs a comprehensive phenotypic analysis of the 5xFAD mouse model across its lifespan, identifying novel age-related pathological features.

Single-cell and nucleus RNA-seq in a mouse model of AD reveal activation of distinct glial subpopulations in the presence of plaques and tangles

The paper uses single-cell and nucleus RNA-seq to analyze glial subpopulations in AD mouse models, finding differences in astrocyte activation and microglia subtypes between 3xTg-AD and 5xFAD models.