Thomas E. Lane

This study infects deermice with SARS-CoV-2 to show infection tolerance extends to novel pathogens, with limited inflammation and effective immune control.

This study investigates how JHMV-induced encephalitis affects Aβ plaque pathology in 5xFAD mice, finding increased T cell infiltration and altered myeloid cell responses.

This study infects 5xFAD mice with SARS-CoV-2 and finds no change in Alzheimer's pathology but widespread gene expression changes in multiple cell types.

This study identifies Escherichia coli as a key driver of B cell accumulation in Peyer's patches via CXCR2-dependent mechanisms involving curli amyloid fibers and TLR2 signaling.

This study identifies OCA-B as a driver of pathogenic maturation in stem-like CD4+ T cells, promoting autoimmune demyelination in multiple sclerosis.

The paper develops a mouse model to specifically target disease-associated microglia (DAMs) using an inducible Cre system and validates its specificity through spatial transcriptomic analysis.