CAR-engineered lymphocyte persistence is governed by a FAS ligand/FAS auto-regulatory circuit
Fei Yi, Tal Cohen, Natalie Zimmerman, Friederike Dündar, Paul Zumbo, Razan Eltilib, Erica J. Brophy, Hannah Arkin, Judith Feucht, Michael V. Gormally, Christopher S. Hackett, Korbinian Nepomuk Kropp, Iñaki Etxeberría, Smita S. Chandran, Zeguo Zhao, , Christopher Austin Klebanoff
This study identifies FASLG expression patterns and shows that FAS-L/FAS auto-regulation governs CAR-T and CAR-NK cell persistence, enhancing antitumor efficacy when FAS is inhibited.
Nature Cancer · Jul 22, 2025Peer-reviewedImmunology