Doron Betel

Hypoxia-activated scleraxis a mediates epicardial progenitor differentiation into a unique cardiac perivascular cell type

This study identifies Scleraxis a as a key regulator of epicardial progenitor differentiation into a unique cardiac perivascular cell type in zebrafish, revealing a hypoxia-responsive pathway involved in coronary vessel development.

Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis

This study investigates how different KRAS mutations drive distinct phenotypic outcomes in pancreatic tumorigenesis, revealing mutation-specific oncogenic pathways and therapeutic implications.

A human developmental and adult brain atlas benchmarks dopaminergic stem cell models and cell therapy candidates

The paper benchmarks dopaminergic stem cell models and cell therapy candidates using a human brain atlas to identify off-target populations and lineage plasticity.

Dynamic Antigen Expression and Intrinsic CTL Resistance in HIV Reservoir Clones

This study characterizes HIV reservoir clones and shows they can be culled by sustained CTL pressure, with some displaying intrinsic resistance linked to low oxidative stress.

Functional interrogation uncovers a critical role for a high-plasticity cell state in lung adenocarcinoma

In vivo lineage tracing and targeted ablation in autochthonous mouse lung adenocarcinoma establish the Slc4a11+ high-plasticity cell state as a bidirectional transition hub driving tumor progression and therapy resistance.

HIV Nef amplifies mechanical heterogeneity to promote immune evasion

This study shows HIV Nef induces a soft phenotype in infected CD4+ T cells, reducing their susceptibility to cytotoxic T lymphocyte killing through cytoskeletal remodeling and intrinsic heterogeneity.

A deep-learning tool for species-agnostic integration of cancer cell states

scVital integrates scRNA-seq data across species to identify conserved cell states and reduce batch effects using a variational autoencoder and discriminator.

Pre-division TCF1 drop determines long-term CD8 T cell fates

This study shows that TCF1 expression drops before CD8 T cells divide, and this drop predicts their long-term fate as effectors or memory cells.

Lysosome-dependent nutrient scavenging underliesstress adaptation during epithelial-to-mesenchymaltransition

This study shows that invasive cancer cells use lysosome-mediated nutrient scavenging during EMT, bypassing plasma membrane transport, and that this process is regulated by c-MYC downregulation.

tRNA modifications are required for stress granule formation and melanoma metastasis

This study shows that tRNA modification mcm5s2U34 is essential for stress granule formation and melanoma metastasis, suggesting it as a therapeutic target.

An IFN-STAT1-CYBB Axis Defines Protective Plasmacytoid DC to Neutrophil Crosstalk During Aspergillus fumigatus Infection.

The paper identifies an IFN-STAT1-CYBB axis that mediates protective crosstalk between plasmacytoid dendritic cells and neutrophils during Aspergillus fumigatus infection.

The EZH2 inhibitor tazemetostat mitigates HIV immune evasion, reduces reservoir formation, and promotes durable CD8+ T-cell revitalization

The paper shows that tazemetostat reduces HIV reservoirs and improves CD8+ T-cell function by increasing MHC-I expression and promoting anti-HIV immune responses.

Total body irradiation primes CD19-directed CAR T cells against large B-cell lymphoma

This study shows that total body irradiation before CAR T cell infusion enhances their effectiveness against large B-cell lymphoma by improving cytotoxicity and survival outcomes.

Enhanced yield and subtype identity of hPSC-derived midbrain dopamine neuron by modulation of WNT and FGF18 signaling

This study improves the yield and subtype identity of hPSC-derived midbrain dopamine neurons through optimized WNT and FGF18 signaling modulation, enhancing their functional and transcriptional similarity to primary neurons.

Multi-Omic Atlas reveals cytotoxic phenotype and ROS-linked metabolic quiescence as key features of CTL-resistant HIV-infected CD4+ T-cells

TNF-NFkB-p53 axis restricts in vivo survival of hPSC-derived dopamine neuron

The paper identifies p53-mediated apoptosis and TNF-NFkB signaling as key factors limiting survival of grafted dopamine neurons and shows that adalimumab treatment improves their engraftment and function in a PD mouse model.

Activation of an injury-associated transient progenitor state in the epicardium is required for zebrafish heart regeneration

The paper identifies a transient epicardial progenitor cell population in zebrafish that is essential for heart regeneration through single-cell RNA sequencing and functional analysis.

Genetic or transcranial magnetic stimulation of B-RAF-MEK signaling promotes CST axon sprouting and functional regeneration

Genetic or HF-rTMS activation of B-RAF-MEK signaling promotes CST axon sprouting and functional regeneration after spinal cord injury.

Inducible and reversible inhibition of miRNA-mediated gene repression in vivo

This study develops a genetic tool to reversibly inhibit miRNA-mediated gene repression in vivo and shows tissue-specific dependencies on miRNA function for homeostasis and regeneration.

High-resolution in vivo identification of miRNA targets by Halo-Enhanced Ago2 Pulldown

This paper introduces a method to identify miRNA targets in vivo using Halo-Enhanced Ago2 Pulldown and demonstrates its application in mouse models.

Enabling cross-study analysis of RNA-Sequencing data

This paper presents a pipeline to unify RNA-seq data from different studies by removing batch effects, enabling cross-study analysis.