Manisha Mahanty

This study shows that TRPV4 channels regulate valvular interstitial cell-to-myofibroblast differentiation in aortic stenosis by modulating mechanotransduction and PI3K-AKT signaling.

This study identifies how TRPV4 negatively regulates miR-146a expression in macrophages through histone deacetylation, independent of NFκB, Stat1, P38, and AKT pathways, in the context of inflammation and atherosclerosis.

This study identifies miR-146a as a key regulator of the foreign body response to biomaterial implants, showing its role in macrophage function, fibrosis, and FBGC formation.