Shaik O. Rahaman

This study identifies TRPV1 as a key regulator of macrophage fusion and foreign body giant cell formation, independent of TRPV4.

This paper develops an engineered LNP-miR146a system that efficiently delivers miR-146a to reduce inflammation and foreign body giant cell formation in vivo.

This study identifies TRPV4 as a cellular stiffness sensor linking matrix stiffness and atherosclerosis using human tissues and a mouse model.

This study shows that TRPV4 channels regulate valvular interstitial cell-to-myofibroblast differentiation in aortic stenosis by modulating mechanotransduction and PI3K-AKT signaling.

This study identifies TRPV4 as a cellular stiffness sensor in aortic stenosis using human tissues and mouse models.

This study identifies how TRPV4 negatively regulates miR-146a expression in macrophages through histone deacetylation, independent of NFκB, Stat1, P38, and AKT pathways, in the context of inflammation and atherosclerosis.

This study identifies miR-146a as a key regulator of the foreign body response to biomaterial implants, showing its role in macrophage function, fibrosis, and FBGC formation.

This study shows that TYMP promotes abdominal aortic aneurysm (AAA) in mice fed a Western diet by enhancing inflammation, thrombosis, and MMP2 activation while inhibiting vascular smooth muscle cell function.