Karunakaran Reddy Sankaran

This study identifies TRPV1 as a key regulator of macrophage fusion and foreign body giant cell formation, independent of TRPV4.

This paper develops an engineered LNP-miR146a system that efficiently delivers miR-146a to reduce inflammation and foreign body giant cell formation in vivo.

This study shows that TRPV4 channels regulate valvular interstitial cell-to-myofibroblast differentiation in aortic stenosis by modulating mechanotransduction and PI3K-AKT signaling.