Mitra Shabrang

The paper reports the discovery of TCRs specific to vaccine peptides in a patient with osteosarcoma following personalized neoantigen vaccination and in vitro expansion.

This study identifies PRAME as a therapeutic target in NUT carcinoma, showing its high expression and susceptibility to T-cell mediated cytotoxicity via PRAME epitopes presented by HLA Class I molecules.

This study shows alcohol use reduces anti-PD1 immunotherapy efficacy in cancer patients and mouse models by impairing T cell function and anti-tumor immunity.