BiochemistrybioRxivPreprint
Structures of MeCP2 bound to nucleosomes reveal distinct mechanisms of Rett syndrome mutations
Liqi Yao, Carolina Valderrama-Hincapié, Jiarui Song…·Vignesh Kasinath
This study determines cryo-EM structures of MeCP2 bound to nucleosomes and identifies how RTT mutations affect nucleosome interactions and chromatin targeting.