NeurosciencebioRxivPreprint
Top-down control of sustained attention by the medial prefrontal cortex (mPFC)- locus coeruleus (LC) circuit during the rodent continuous performance task (rCPT)
Jason J. Rehg, Daniel E. Olivares, Ye Li…·Jorge A. Miranda-Barrientos
This study investigates the role of the mPFC-LC circuit in sustained attention using chemogenetic manipulation in mice, finding that selective activation of mPFC-LC projectors improves attentional performance through distinct neural mechanisms.
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