Gregory V. Carr

Development of a Novel Benzodiazepine to Delineate Peripheral GABA-A Signaling Mechanisms in Visceral Pain Syndromes

This study develops a novel benzodiazepine, Li633, that targets peripheral GABAA receptors to reduce visceral pain in IBS and FD models.

Top-down control of sustained attention by the medial prefrontal cortex (mPFC)- locus coeruleus (LC) circuit during the rodent continuous performance task (rCPT)

This study investigates the role of the mPFC-LC circuit in sustained attention using chemogenetic manipulation in mice, finding that selective activation of mPFC-LC projectors improves attentional performance through distinct neural mechanisms.

Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test

The paper examines how neural activity in the prelimbic cortex correlates with attentional behavior in mice during the rodent continuous performance test.

Time-on-task-related decrements in performance in the rodent continuous performance test are not caused by physical disengagement from the task

This study shows that performance decline in the rodent Continuous Performance Test (rCPT) over time is due to vigilance decrements, not physical disengagement, and amphetamine improves performance without affecting task engagement.

Electrophysiological correlates of attention in the locus coeruleus - anterior cingulate cortex circuit during the rodent continuous performance test

Stimulus degradation impairs performance in a rodent continuous performance test

This study shows that degraded stimuli impair performance in a mouse continuous performance test, mirroring human findings and supporting the translational value of the rodent model.

Post-weaning social isolation modulates reward-seeking behavior in a sex-specific manner in mice

This study shows that adolescent social isolation in mice affects reward-seeking behavior differently in males and females, with males showing increased sensitivity and reward-seeking.

Post-weaning social isolation increases ΔFosB/FosB protein expression in the prefrontal cortex and hippocampus in mice

Novel, non-nitrocatechol COMT inhibitors modulate dopamine neurotransmission in the frontal cortex and improve cognitive flexibility

The paper identifies novel COMT inhibitors that improve cognitive flexibility in rats by modulating dopamine metabolites in the frontal cortex and cerebrospinal fluid.

Effects of catechol-O-methyltransferase inhibition on effort-related choice behavior in male mice

This study investigates the effects of COMT inhibition on effort-related choice behavior in male mice and finds no significant impact on task performance.

Development of a PC12 cell-based assay for in vitro screening of catechol-O-methyltransferase inhibitors

This study evaluates the use of PC12 cells as an in vitro platform to screen COMT inhibitors, showing that tolcapone and LIBD-3 increase dopamine and DOPAC while reducing 3-MT and HVA.