Jason J. Rehg

This study investigates the role of the mPFC-LC circuit in sustained attention using chemogenetic manipulation in mice, finding that selective activation of mPFC-LC projectors improves attentional performance through distinct neural mechanisms.

The paper examines how neural activity in the prelimbic cortex correlates with attentional behavior in mice during the rodent continuous performance test.

This study shows that performance decline in the rodent Continuous Performance Test (rCPT) over time is due to vigilance decrements, not physical disengagement, and amphetamine improves performance without affecting task engagement.