BioengineeringiSciencePeer-reviewed
Mechanical Resistance to Micro-Heart Tissue Contractility unveils early Structural and Functional Pathology in iPSC Models of Hypertrophic Cardiomyopathy
Jingxuan Guo, Huanzhu Jiang, David R. Schuftan…·Nathaniel Huebsch
This study uses iPSC-derived heart tissue models to show that mechanical stress exacerbates HCM-linked MYBPC3 mutations, leading to structural and functional cardiac pathology.
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