Huanzhu Jiang

Tunable Magnetorheological Elastomer Substrates for Studying Mechano-Genetic Interactions in Hypertrophic Cardiomyopathy

This study uses tunable magnetorheological elastomer substrates to investigate mechano-genetic interactions in HCM by applying dynamic mechanical stress to hiPSC-derived cardiomyocytes with a MYBPC3 mutation.

Mechanical history shapes phenotypic plasticity and fibroblast-autonomous 3D remodeling in iPSC-derived cardiac fibroblasts

This study shows that mechanical culture history affects iPSC-derived cardiac fibroblasts' phenotype and TGF-beta1 response, but later passages can alter these effects.

A Micro-Engineered Heart Tissue Model of Desmin-related Cardiomyopathy Caused by Mutant αB Crystalin

This paper develops a micro-engineered heart tissue model of desmin-related cardiomyopathy caused by mutant αB crystallin, showing aggregation, contractile dysfunction, and potential therapeutic response to JAK1 inhibition.