Cheuk‐Ting Law

The paper develops TiMEstamp to identify LINE-1 chimeric insertions in the human genome, revealing new chimeras and mechanisms like trans-splicing.

The paper investigates how L1 retrotransposition intermediates can recombine with DNA breaks or other L1 insertions to form chromosomal rearrangements, showing dependence on ORF2p and BRCA1.

The paper introduces CELLO-seq, a long-read RNA sequencing method for single cells, to study TE expression in mouse and human cells, finding locus-specific expression and regulatory heterogeneity.