Steven Gershik

The paper shows that inactive PARP2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts, explaining PARPi-induced hematological toxicities.

This study shows that catalytically inactive PARP1 causes embryonic lethality and genome instability in a dominant-negative manner, revealing its severe impact on normal tissues.

This study shows ATR kinase prevents replication resource exhaustion in early S phase, supporting normal cell proliferation by regulating origin firing.