Author
Columbia UniversityORCID 0000-0002-8265-0474Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Xiaohui Lin, Zhengping Shao, Denitsa Yaneva, Wenxia Jiang, Demis Menolfi, Seema Khattri Bhandari, Brian J. Lee, Mirjam Schmucker, Faye Yaneva, Alan E. Tomkinson, Julian Stingele, Shan Zha
This study shows that catalytically inactive PARP1, not PARP2, is responsible for PARP inhibitor-induced hematological toxicity in mice.
bioRxiv · Sep 25, 2026 · PreprintCancer Biology
Xiaohui Lin, Dipika Gupta, Alina Vaitsiankova, Seema Khattri Bhandari, Kay Sze Karina Leung, Demis Menolfi, Brian J. Lee, Helen R. Russell, Steven Gershik, Xiaoyu Huang, Wei Jun Gu, Peter J. McKinnon, Françoise Dantzer, Eli Rothenberg, Alan E. Tomkinson, Shan Zha
The paper shows that inactive PARP2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts, explaining PARPi-induced hematological toxicities.
Molecular Cell · Oct 1, 2024Peer-reviewedGenetics
Zhengping Shao, Brian J. Lee, Hanwen Zhang, Xiaohui Lin, Chen Li, Wenxia Jiang, Napon Chirathivat, Steven Gershik, Michael M. Shen, Richard J. Baer, Shan Zha
This study shows that catalytically inactive PARP1 causes embryonic lethality and genome instability in a dominant-negative manner, revealing its severe impact on normal tissues.
Proceedings of the National Academy of Sciences · Jul 24, 2023Peer-reviewedGenetics