Author
Columbia UniversityORCID 0000-0002-3824-9931Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Xiaohui Lin, Zhengping Shao, Denitsa Yaneva…·Shan Zha
This study shows that catalytically inactive PARP1, not PARP2, is responsible for PARP inhibitor-induced hematological toxicity in mice.
Xiaohui Lin, Dipika Gupta, Alina Vaitsiankova…·Shan Zha
The paper shows that inactive PARP2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts, explaining PARPi-induced hematological toxicities.
Demis Menolfi, Brian J. Lee, Hanwen Zhang…·Shan Zha
This study shows ATR kinase prevents replication resource exhaustion in early S phase, supporting normal cell proliferation by regulating origin firing.