Author
Columbia UniversityORCID 0000-0002-5097-0975Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Xiaohui Lin, Zhengping Shao, Denitsa Yaneva…·Shan Zha
This study shows that catalytically inactive PARP1, not PARP2, is responsible for PARP inhibitor-induced hematological toxicity in mice.
Zhengping Shao, Brian J. Lee, Hanwen Zhang…·Shan Zha
This study shows that catalytically inactive PARP1 causes embryonic lethality and genome instability in a dominant-negative manner, revealing its severe impact on normal tissues.
Demis Menolfi, Brian J. Lee, Hanwen Zhang…·Shan Zha
This study shows ATR kinase prevents replication resource exhaustion in early S phase, supporting normal cell proliferation by regulating origin firing.