Mari B. Gornitzka

GATHeR reconstructs full-length, paired B-cell receptor sequences from scRNA-seq data, improving subclass, allele, and isoform resolution, especially in naive and memory B cells.

The paper identifies putative antigen targets of a stereotyped intrathecal B cell response in multiple sclerosis by generating monoclonal antibodies and using IPMS/MS to screen against proteins.

The paper introduces a method using ultra-long sequencing and bioinformatics to resolve haplotypes in the human immunoglobulin heavy chain locus, uncovering novel alleles and structural variants.