Transcription of Repeats Activates INterferon (TRAIN) in response to chromatin destabilization induced with anti-cancer small molecule
Katerina I. Leonova, Alfiya F. Safina, Elimelech Nesher, Poorva Sandlesh, Rachel N. Pratt, Catherine A. Burkhart, Britney Lipchick, Costakis G. Frangou, Igor E. Koman, Jianmin Wang, Кирсанов Кирилл Игоревич, Якубовская Марианна Геннадиевна, Andrei V. Gudkov, Katerina V. Gurova
The paper shows that chromatin destabilizing drugs like curaxin induce an interferon response (TRAIN) through repeat transcription, independent of p53 status, and may prevent cancer by eliminating epigenetically unstable cells.
bioRxiv · Jun 28, 2017 · PreprintMolecular Biology