Andrei V. Gudkov

This study identifies NAMPT as a metabolic vulnerability in HR-MDS HSPCs, showing its inhibition reduces their survival and disease burden.

TLR5 deficiency is linked to pulmonary fibrosis due to its role in preventing microbial dysbiosis following lung injury.

This study tests an mRNA-encoded TLR5 agonist as an adjuvant to enhance mRNA vaccine immunogenicity and efficacy.

The paper tracks aging in sled dogs using a variational autoregressive model to show that lamivudine temporarily decelerates DNA methylation clocks but not long-term biological age.

This paper develops a deep learning model to identify a blood-based biomarker of aging in mice using phenotypic data, finding it correlates with aging hallmarks and predicts lifespan.

The paper analyzes longitudinal blood marker data to show aging is associated with declining physiological resilience and predicts a lifespan limit around 120-150 years.

The paper quantifies biological age and frailty using locomotor activity data from NHANES and UKB, linking aging trajectories to mortality and health outcomes.

The paper shows that chromatin destabilizing drugs like curaxin induce an interferon response (TRAIN) through repeat transcription, independent of p53 status, and may prevent cancer by eliminating epigenetically unstable cells.