Margaux Quiniou

This study shows that CENP-A, a centromere-specific histone variant, is dynamically regulated by synaptic activity in neurons and is required for activity-dependent gene expression and hippocampus-dependent learning and memory.

The paper shows that mutations in the Drosophila Asp gene, which is homologous to ASPM, cause tissue-specific vulnerabilities to mitotic defects, leading to microcephaly and midgut abnormalities.