Sebastian Jessberger

This study shows that CENP-A, a centromere-specific histone variant, is dynamically regulated by synaptic activity in neurons and is required for activity-dependent gene expression and hippocampus-dependent learning and memory.

The paper identifies ECM remodeling differences between slowly and rapidly dividing RGCs that regulate aNSC emergence and pool size through in vivo perturbation and single-cell RNA-sequencing.

This study identifies injury-induced plastic astrocytes in mice that exhibit self-renewal and neurosphere-forming capabilities, resembling transit-amplifying progenitors in transcriptional profile.

The paper shows that mature astrocytes can transform into progenitor-like cells to regenerate astrocytic networks after injury in mice.

The paper shows asymmetric inheritance of centrosomes in human neural progenitor cells, maintaining self-renewal and proper neurogenesis.

The paper shows human neural progenitors form an ER diffusion barrier during cell division, enabling asymmetric segregation of damaged proteins.

This study uses iterative immunofluorescence imaging to analyze age-related changes in the dentate gyrus niche, identifying reorganization and microenvironmental changes affecting neurogenesis in mice.