Gerd Kempermann

Co-option of CENP-A for activity-induced neuronal plasticity

This study shows that CENP-A, a centromere-specific histone variant, is dynamically regulated by synaptic activity in neurons and is required for activity-dependent gene expression and hippocampus-dependent learning and memory.

Mice sense Moon and Sun

The paper reports that mice exhibit behavioral activity with ~14 and ~28 day periodicity, aligned with geomagnetic fluctuations from the Moon and Sun, independent of circadian rhythms.

The Pgb1 locus controls glycogen aggregation in astrocytes of the aged hippocampus without impacting cognitive function

The paper identifies the Pgb1 locus as controlling glycogen aggregation in aged hippocampal astrocytes without affecting cognitive function.

Experience Reorganizes Coordinated Population Dynamics Across Hippocampal Circuits

The paper shows that long-term experience reorganizes coordinated population dynamics across hippocampal circuits in mice, altering activity patterns across subfields.

Mapping Large-scale Spatiotemporal Dynamics of Synaptic Plasticity and LTP for Memory Encoding in the Hippocampal Network

This paper introduces EVOX, a platform for mapping synaptic plasticity and LTP in hippocampal networks, showing high-frequency stimulation induces network-wide LTP.

MEA-seqX: High-resolution Profiling of Large-scale Electrophysiological and Transcriptional Network Dynamics

MEA-seqX integrates electrophysiological and transcriptional data to reveal coordinated spatiotemporal dynamics in hippocampal circuits and identify cell types based on bimodal profiles.

Genetic Modulation of Protein Expression in Rat Brain

This study quantifies protein expression in rat brains, identifies pQTLs, and links them to behavioral traits and human disorders.

Exploring social modulation: Microglia as a key mediator of individual immune response, plasticity and pathology in App-NL-G-F mouse model of Alzheimer's disease

This study investigates how social environment affects Alzheimer's disease progression in App-NL-G-F mice, showing social deficits precede pathology and linking microglia activation to neuroinflammation and neurogenesis.

Rich Experience Boosts Functional Connectome and High-Dimensional Coding in Hippocampal Network

This study shows that environmental enrichment increases functional connectivity and high-dimensional coding in hippocampal networks of mice through ex vivo recordings.

Individual behavioral trajectories shape whole-brain connectivity in mice

The paper shows that different behavioral patterns in mice lead to distinct brain connectivity patterns in an enriched environment.

Lifelong musical activity is associated with multi-domain cognitive and brain benefits in older adults

This study finds that lifelong musical activity is linked to better cognitive abilities and preserved brain structure in older adults, suggesting it may enhance cognitive resilience.

Pre-symptomatic reduction of individuality in the App NL-F knock-in model of Alzheimer's disease

The paper examines how the AppNL-F mutation affects pre-symptomatic behavioral and physiological responses to environmental enrichment in mice, revealing lasting effects on brain plasticity.

De novo DNA methylation controls neuronal maturation during adult hippocampal neurogenesis

Adult-born neurons promote cognitive flexibility by improving memory precision and indexing

This study shows that increasing adult-born neurons improves memory precision and indexing, contributing to cognitive flexibility.

Epigenetic rejuvenation of the hippocampus by environmental enrichment

This study shows environmental enrichment counteracts age-related DNA methylation changes in the hippocampus of mice, preventing CpG hypomethylation at Mecp2 target sites and preserving neuronal functions.

System genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose

The paper identifies Tti2 as a gene influencing both adult hippocampal neurogenesis and serum glucose levels using a rat genetic model.

Apple peel and flesh contain pro-neurogenic compounds

This study identifies pro-neurogenic compounds in apple peel and flesh that enhance hippocampal neurogenesis in adult mice through distinct mechanisms.

Redox potential defines functional states of adult hippocampal stem cells

The paper identifies high ROS levels in quiescent adult hippocampal stem cells and shows how physical activity triggers their activation through a Nox2-dependent ROS surge.

Early-life environmental enrichment generates persistent individualized behavior in mice

This study shows that early-life environmental enrichment in mice leads to persistent individualized behaviors and lasting epigenetic changes in the hippocampus.

Selective increases in inter-individual variability in response to environmental enrichment

The paper shows that enriched environment increases inter-individual variability in brain and behavior traits in mice.

Continuous high-resolution in vivo imaging reveals tumor-specific dissemination in an embryonic zebrafish xenograft model

This study uses a transparent zebrafish model to track human cancer cell dissemination in real time, revealing differences in metastatic behavior between leukemic and breast cancer cells.