BiochemistrybioRxivPreprint
Pervasive aggregation and depletion of host and viral proteins in response to cysteine-reactive electrophilic compounds
Ashley R. Julio, Flowreen Shikwana, Cindy C. Truong…·Keriann M. Backus
The paper identifies a cysteine-reactive small molecule degrader of SARS-CoV-2 nsp14, showing it causes protein aggregation, depletion, and stress granule formation in cells.
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