ImmunologybioRxivPreprint
Homeostatic fibroblast niche collapse in clinically uninvolved skin marks a pre-fibrotic stage of systemic sclerosis
Alex Hu, Lin Wei Tung, Thomas Pulliam…·Peter J Morawski
The paper identifies a pre-fibrotic stage in scleroderma by analyzing spatial transcriptomic changes in clinically uninvolved skin, showing early loss of fibroblast niches and vascular reprogramming.
DOI 10.64898/2026.11.05.764714