Samuel M. Young

Presynaptic CaV2.1 calcium dependent facilitation is essential for faithful auditory information transfer

The paper investigates the role of CaV2.1 calcium-dependent facilitation in auditory synaptic transmission, finding that its absence reduces synaptic reliability and precision.

Pre-Sensory Spontaneous Activity Accelerates Coordinated Maturation of Synaptic Partners and Drives Transition to the Mature Physiological Phenotype

The paper shows that pre-sensory spontaneous activity initiates and drives synaptic maturation but can be partially compensated for in its absence.

Prevenying vision loss in a mouse model of Leber Congenital Amaurosis by engineered tRNA

This study demonstrates that engineered tRNA can restore vision in a mouse model of Leber Congenital Amaurosis by suppressing a premature termination codon.

CaV2.1 α1 subunit motifs that control presynaptic CaV2.1 subtype abundance are distinct from CaV2.1 preference

The paper investigates motifs in CaV2.1 subunits that regulate presynaptic abundance and preference, finding distinct motifs control abundance versus preference.

Presynaptic Rac1 controls synaptic strength through the regulation of synaptic vesicle priming.

This study shows that presynaptic Rac1 regulates synaptic strength by controlling synaptic vesicle priming and release probability in mouse calyx of Held synapses.

Presynaptic development is controlled by the core active zone proteins CAST/ELKS

The paper investigates the role of CAST/ELKS in presynaptic development, finding reduced surface area and increased active zone size but no impairment in synaptic transmission.

Presynaptic mitochondria volume and abundance increase during development of a high-fidelity synapse

The paper measures mitochondrial volume changes in calyx of Held synapses during development and finds increased mitochondrial volumes from postnatal day 7 to 21.