Author

Raoul Frijters

Rijk Zwaan (Netherlands)ORCID 0009-0006-6520-9552Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:plant (other)· 3 Assay:protein structure· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1 Approach:deep learning· 1 Approach:experimental assay· 1

Frequent Co-Authors

AmirAli ToghaniiD· 3 shared Sophien KamouniD· 3 shared Mauricio P. ContrerasiD· 2 shared Yu SugiharaiD· 2 shared Andrés PosbeyikianiD· 1 shared Hiroaki AdachiiD· 1 shared Hsuan PaiiD· 1 shared Jiorgos KourelisiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersPlant Biology

AmirAli ToghaniORCID

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3 papers

Recent·Most cited

Plant BiologybioRxivPreprintMay 20, 2026

A conserved structural logic underlies sensor-helper NLR communication in the NRC immune receptor network

AmirAli Toghani, Maián Garro, Raoul Frijters…·Mauricio P. Contreras

The paper identifies conserved sensor-helper NLR interfaces in the NRC immune receptor network and validates their role in immune activation through structural and functional studies.

2 citations

plant (other)protein structure

𝕏 PostBluesky

Plant BiologyNew PhytologistPeer-reviewedJul 15, 2025

✦ In-depth digest

Can AI modelling of protein structures distinguish between sensor and helper NLR immune receptors?

AmirAli Toghani, Raoul Frijters, Tolga O. Bozkurt…·Yu Sugihara

AlphaFold 3 oligomer models separate paired plant NLRs: helpers score higher pTM and form funnel-shaped resistosomes unlike sensors, including some rice pairs lacking integrated-domain annotations.

15 citationstop 2%

plant (other)protein structure

𝕏 PostBluesky

Plant BiologybioRxivPreprintFeb 25, 2025

A hierarchical immune receptor network in lettuce reveals contrasting patterns of evolution in sensor and helper NLRs

Hsuan Pai, Toshiyuki Sakai, Andrés Posbeyikian…·AmirAli Toghani

The paper analyzes NLR evolution in lettuce and related species, finding that sensor NLRs evolve faster than helper NLRs and that sensor diversification is linked to helper dependency.

7 citations

plant (other)comparative / phylogenetic analysis

𝕏 PostBluesky