Liying Xue

This study links clonal hematopoiesis to accelerated frailty and functional decline across multiple organ systems in humans.

This paper shows that rhodopsin's light protection mechanism evolved to sequester toxic retinal and protect retinal cells, with implications for human disease.

This study finds that clonal hematopoiesis (CHIP) increases stroke risk across multiple cohorts, with specific gene mutations and inflammatory markers like IL-1RAP modifying this risk.

The paper benchmarks somatic variant and indel detection at low allele fractions using short- and long-read data, finding sensitivity and precision around 80% at 300x coverage.

The paper identifies genetic drivers and clinical consequences of mosaic chromosomal alterations in 1 million individuals, linking specific aut-mCAs to disease risk and therapeutic targets.

The paper examines heteroplasmic mitochondrial genetic variants in human cardiac tissues and finds they differ from those in blood and skeletal muscle, with higher variant counts in cardiac tissue linked to age.