Author

Gianni M. Castiglione

Johns Hopkins UniversityORCID 0000-0002-0768-4236Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. A. BoseiD· 1 shared Alexander G. BickiD· 1 shared Amanda J. LeaiD· 1 shared Audrey M. ArneriD· 1 shared Chien‐Fu HungiD· 1 shared Elia J. DuhiD· 1 shared Isabella Bautista· 1 shared Jinger N Hayes· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiochemistry

A. A. BoseORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Evolutionary tuning of rhodopsin-mediated light protection

Nadir H Dbouk, Madeleine Bagshaw, A. A. Bose, Marselle A. Rasdall, Audrey M. Arner, Kun Zhao, Kaitlin E Taylor, Neena Praveen, Weihong Huo, Isabella Bautista, Narmin Musayeva, Liying Xue, Jinger N Hayes, Marin McElhinney, Rohan Kasthuri, , Gianni M. Castiglione

This paper shows that rhodopsin's light protection mechanism evolved to sequester toxic retinal and protect retinal cells, with implications for human disease.

bioRxiv · May 27, 2026 · PreprintBiochemistry

The ancient cardioprotective mechanisms of ACE2 bestow SARS-CoV-2 with a wide host range

Gianni M. Castiglione, Lingli Zhou, Zhenhua Xu, Zachary M. Neiman, Chien‐Fu Hung, Elia J. Duh

The paper shows SARS-CoV-2 exploits ACE2's catalytic activity to infect a wide range of species through specific mutations that block viral binding.

bioRxiv · Jan 3, 2021 · PreprintMolecular Biology