Valerie F. A. March

This study investigates how antibiotic tolerance evolves in Mycobacterium tuberculosis during treatment and finds no evidence that it contributes to delayed culture conversion.

The paper measures drug tolerance in Mycobacterium tuberculosis lineages and finds higher tolerance in L3 and L4 strains, with heritable patterns and enrichment of mutations in specific metabolic pathways.

The paper shows that epistatic interactions between RpoB and GyrA mutations in Mycobacterium tuberculosis can lead to high-fitness double-resistant strains, which are prevalent in clinical isolates.

The paper shows that antibiotic treatment affects Mycobacterium tuberculosis culturability, with differential effects on colony formation and liquid culture growth.