Miriam Reinhard

Within-host evolution of drug tolerance in Mycobacterium tuberculosis.

This study investigates how antibiotic tolerance evolves in Mycobacterium tuberculosis during treatment and finds no evidence that it contributes to delayed culture conversion.

Variability in intrinsic drug tolerance in Mycobacterium tuberculosis corresponds with phylogenetic lineage

The paper measures drug tolerance in Mycobacterium tuberculosis lineages and finds higher tolerance in L3 and L4 strains, with heritable patterns and enrichment of mutations in specific metabolic pathways.

Epistasis between drug resistance-conferring mutations in Mycobacterium tuberculosis

The paper shows that epistatic interactions between RpoB and GyrA mutations in Mycobacterium tuberculosis can lead to high-fitness double-resistant strains, which are prevalent in clinical isolates.

Soluble immune mediators orchestrate protective in vitro granulomatous responses across Mycobacterium tuberculosis complex lineages

This study examines how different Mycobacterium tuberculosis complex lineages elicit varying granulomatous responses in vitro, linking genetic diversity to immune activation and bacterial growth.

Using population-specific add-on polymorphisms to improve genotype imputation in underrepresented populations

The paper improves genotype imputation in underrepresented populations by adding population-specific SNPs to existing reference panels, showing improved accuracy in a Tanzanian cohort.

Local adaptation in populations of Mycobacterium tuberculosis endemic to the Indian Ocean Rim

The paper analyzes whole genome sequences of Mycobacterium tuberculosis lineages L1 and L3 to show South Asia's role in their dispersion and identify local adaptation at the esxH locus.