BioengineeringbioRxivPreprint
A lipid nanoparticle platform for high yield CRISPR-targeted homology directed repair enables fully non-viral CAR T cell generation
Joy J. Chen, Atip Lawanprasert, A.L.W. Kleinhenz…·David N. Nguyen
This paper develops a lipid nanoparticle (LNP) platform for non-viral CRISPR-mediated homology directed repair (HDR) to generate CAR T cells with improved efficiency and reduced toxicity compared to electroporation.
DOI 10.64898/2026.08.04.741347