Author

Mohammed Ali H. Alfadhel

Massachusetts General HospitalORCID 0009-0007-2865-5403Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:imaging· 1

Frequent Co-Authors

Sava SakadžićiD· 2 shared Sergei A. VinogradoviD· 2 shared Anna DevoriD· 1 shared Ava Devine· 1 shared Baoqiang LiiD· 1 shared Buyin Fu· 1 shared Cenk AyataiD· 1 shared Chongzhao RaniD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersNeuroscience

Sava SakadžićORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintOct 16, 2026

Depth-Dependent Alterations in Cerebral Blood and Tissue Oxygenation Associated with Tau in Alzheimer's Disease Models

Nancy E. Ruiz‐Uribe, Mohammed Ali H. Alfadhel, Nina Wolf…·Rachel E. Bennett

This study examines depth-dependent changes in cerebral oxygenation in Alzheimer's disease models, finding that tau disrupts oxygen levels and that neuronal loss is not due to local hypoxia.

DOI 10.64898/2026.10.09.757981

mouseimaging

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NeuroscienceeLifePeer-reviewedJun 19, 2023

Aerobic exercise reverses aging-induced depth-dependent decline in cerebral microcirculation

Paul Shin, Qi Pian, Hidehiro Ishikawa…·Sava Sakadžić

This study shows aerobic exercise improves microvascular perfusion and oxygenation in deep brain regions of aged mice, correlating with better cognitive function.

19 citations

mouseexperimental assay

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