Sergei A. Vinogradov

Sex shapes capillary flows and oxygen extraction in the middle-aged mouse brain

The paper shows that female mice have higher cortical blood flow and reduced oxygen extraction fraction in middle age, with molecular and structural differences in white matter and microglial reactivity, without differences in systemic markers.

Depth-Dependent Alterations in Cerebral Blood and Tissue Oxygenation Associated with Tau in Alzheimer's Disease Models

This study examines depth-dependent changes in cerebral oxygenation in Alzheimer's disease models, finding that tau disrupts oxygen levels and that neuronal loss is not due to local hypoxia.

ECgo: All-Optical Induction of Single Endothelial Cell Injury and Capillary Occlusion in the Brain

The paper introduces ECgo, an optical method to induce single endothelial cell injury and capillary occlusion in the mouse brain with high spatial precision, enabling studies of capillary repair and dysfunction.

Multimodal retinal imaging by visible light optical coherence tomography and phosphorescence lifetime ophthalmoscopy in the mouse eye

This study develops a multimodal imaging system combining VIS-OCT and PLIM-SLO to simultaneously capture retinal structure and capillary oxygen levels in mice.

Global hypoperfusion leads to a mismatch in oxygen delivery and consumption in the cerebral watershed area

This study investigates how global hypoperfusion affects oxygen delivery and consumption in the cerebral watershed area compared to the MCA territory using in vivo imaging techniques in mice.

Shallow-angle intracranial cannula for repeated infusion and in vivo imaging with multiphoton microscopy

The paper introduces a shallow-angle cannula for repeated drug delivery and in vivo imaging in mice, demonstrating its use for tracking degenerating neurons and measuring brain oxygen levels.

Carbonic anhydrase inhibitors prevent presymptomatic capillary flow disturbances in a model of cerebral amyloidosis

This study shows carbonic anhydrase inhibitors prevent capillary flow issues in a mouse model of early Alzheimer's disease before symptoms appear.

Aerobic exercise reverses aging-induced depth-dependent decline in cerebral microcirculation

This study shows aerobic exercise improves microvascular perfusion and oxygenation in deep brain regions of aged mice, correlating with better cognitive function.

Homogenization of capillary flow and oxygenation in deeper cortical layers correlates with increased oxygen extraction

The paper measures capillary flow and oxygenation in cortical layers of awake mice, finding homogenization of oxygen delivery and increased extraction in layer IV.