Nancy E. Ruiz‐Uribe

This study examines depth-dependent changes in cerebral oxygenation in Alzheimer's disease models, finding that tau disrupts oxygen levels and that neuronal loss is not due to local hypoxia.

The paper shows tau accumulates around blood vessels in Alzheimer's disease brains and is linked to tau tangle pathology.

This study shows that inhibiting NOX2 reduces capillary stalling and inflammation in Alzheimer's mice, improving memory and blood flow.

This study shows that inhibiting VEGF signaling in AD mice reduces leucocyte adhesion in brain capillaries, increases blood flow, and improves BBB integrity.

This study shows that voluntary running improves memory and neurogenesis in Alzheimer's mouse models but does not increase cerebral blood flow or reduce amyloid-beta deposits.

The paper shows that a high fat diet worsens Alzheimer's disease symptoms in mice but does not synergistically reduce cerebral blood flow, suggesting capillary stalling is not the mechanism linking diet and disease severity.