Shayan Hajhashemi

This study shows that neutrophil extracellular traps (NETs) in lymph nodes create an immunosuppressive environment that promotes metastasis by altering Treg and CD8 T cell function and organization.

This study shows that RORγ inverse agonism reduces tumor progression by altering myeloid cell organization and immune responses in gastroesophageal adenocarcinoma.

This study links circulating myeloid dysfunction, measured by cNLR, to tumour spatial organization in GEA through multiscale analyses of immune function, single-cell transcriptomics, and spatial myeloid organization.

DiffDose uses automatic differentiation to optimize drug dosing regimens by turning mechanistic PK/PD and QSP models into gradient-based tools for personalized treatment design.

This paper introduces scLSD, a thermodynamics-inspired model for cell differentiation that reconstructs differentiation trajectories and predicts fate commitment, outperforming existing methods.