Jonathan Cools‐Lartigue

Neutrophil Extracellular Trap Deposition Establishes an Immunosuppressive Environment in Non-metastatic Lymph Nodes and Facilitates Heterologous Metastatic Outgrowth

This study shows that neutrophil extracellular traps (NETs) in lymph nodes create an immunosuppressive environment that promotes metastasis by altering Treg and CD8 T cell function and organization.

RORγ Inverse Agonism Redirects Tumour-Conditioned Emergency Myelopoiesis and Attenuates Established Tumour Progression

This study shows that RORγ inverse agonism reduces tumor progression by altering myeloid cell organization and immune responses in gastroesophageal adenocarcinoma.

A Measurable Systemic Immune Phenotype Links Circulating Myeloid Dysfunction to Tumour Spatial Organization in Gastroesophageal Adenocarcinoma

This study links circulating myeloid dysfunction, measured by cNLR, to tumour spatial organization in GEA through multiscale analyses of immune function, single-cell transcriptomics, and spatial myeloid organization.