Author

Jacob M. Hughes

Uniformed Services University of the Health SciencesORCID 0009-0007-6686-5014Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Amanda J. LinkeiD· 1 shared Andrew M. FrankiD· 1 shared Brianna R. DaleyiD· 1 shared Bridget A. FinniffiD· 1 shared Clifton L. DalgardiD· 1 shared Daniel GerlachiD· 1 shared Erin SheffelsiD· 1 shared Joseph P. LaMorteiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Amanda J. LinkeORCID

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1 paper

Recent·Most cited

Cancer BiologyCancer ResearchPeer-reviewedOct 22, 2024

SOS1 inhibition enhances the efficacy of and delays resistance to G12C inhibitors in lung adenocarcinoma

Brianna R. Daley, Nancy E. Sealover, Bridget A. Finniff…·Robert L. Kortum

This study shows that SOS1 inhibition with BI-3406 enhances G12C inhibitor efficacy and delays resistance in lung adenocarcinoma by targeting resistance mechanisms and drug-tolerant persister cells.

20 citationstop 3%

humanexperimental assay

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