Author

Nicholas T. Smith

Queen's UniversityORCID 0009-0007-6705-6390Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:bacteria (other)· 2 Approach:statistical model· 2 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

George Colin diCenzoiD· 3 shared Graeme W. HoweiD· 3 shared Amira BoukherissaiD· 1 shared Autumn J. HodginsiD· 1 shared Benoît AlunniiD· 1 shared Chantelle J. CapicciottiiD· 1 shared Jacqui Anne ShykoffiD· 1 shared Kiera Antaya· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersBiochemistry

George Colin diCenzoORCID

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 6, 2026

Evolution and remodeling of acceptor specificity in the NodZ α-1,6-fucosyltransferase

Nicholas T. Smith, George Colin diCenzo, Graeme W. Howe

This study investigates the evolution of acceptor specificity in NodZ fucosyltransferases, identifying key residues and evolutionary changes that influence substrate preference.

DOI 10.64898/2026.10.04.756492

statistical model

𝕏 PostBluesky

BiochemistrybioRxivPreprintAug 5, 2025

Characterization of bacterial fucokinase/GDP-fucose pyrophosphorylase (FKP) enzymes supports the evolution of interdomain communication and modularity in the FKP family

Nicholas T. Smith, Autumn J. Hodgins, Marie E. Boddington…·Graeme W. Howe

This study characterizes bacterial FKP enzymes, revealing evolutionary origins and functional diversity through biochemical and phylogenetic analyses.

DOI 10.1101/2025.08.05.668714

bacteria (other)proteomics

𝕏 PostBluesky

MicrobiologyMicrobial GenomicsPeer-reviewedApr 16, 2025

Taxonomic distribution of SbmA/BacA and BacA-like antimicrobial peptide transporters suggests independent recruitment and convergent evolution in host-microbe interactions

Nicholas T. Smith, Amira Boukherissa, Kiera Antaya…·George Colin diCenzo

This study identifies the distribution of SbmA/BacA and BclA antimicrobial peptide transporters across bacteria, showing convergent evolution and their role in host-microbe interactions.

6 citations

bacteria (other)statistical model

𝕏 PostBluesky